Is there a reason why rogaine and finasteride only work on the vertex but not the receding hairline/frontal area?

Many aspects of the mechanism of action of Rogaine and finasteride (Propecia) are still unknown, and for that same reason we do not know why they work on the vertex better than the temple and frontal area. I can guess that reversal of frontal hair loss is very rare, because by the time the treatments are started, the balding has gone too far as it starts earlier. Crown balding is slower and from the time it is first recognized, it often early in the thinning process. As such, reversal of crown loss is much more common with these medications, particularly in the young man under 35 years old. However, finasteride does work to slow down or stop hair loss in the frontal area, particularly if caught early enough.

Balding Forum - Hair Loss Discussion

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