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Category Archive for Hair Cloning

 

What is Confusing About The Dr Gho Patient Diary on Hair Regeneration?

Dear Dr. Rassman,

you stated in a previous post that the pictures of the Dr. Gho patient is “confusing”. Could you be more elaborate on this topic? Why do you say so? In your previous post concerning Dr. Gho you stated that a follow up video would be nice. Aren’t these photographs followup documentation. It clearly shows regrowth. I used photoshop to lay the before and after images over each other. It is definately the same hair region displaying how the follicles are regrowing from the extraction sites. Why do you still consider this deceptive?

Regards

For those that missed it, the original post is here.

Has anyone ever stopped and considered that maybe the regeneration you are seeing is just regular hairs (missed FUEs) growing back? I mean, what about the photos of the recipient site? Did anyone count the number or percentage of transplanted hairs that actually GREW?

If 1000 hairs were harvested, 700 of the transplanted hairs grew in the new location and 300 hairs regrew in the harvested donor area, would you consider this regrowth or hair multiplication or hair stem cell transplantation? Of course not! But you can take pictures of the donor area and show regrowth, and take pictures of the transplanted area and also show growth. The observer could think, “Wow! This is regeneration!” — but the observer would be mistaken. To show regeneration, duplication, cloning, stem cell transplant regeneration, or an outcome that showed splitting of the hairs, you must account for ALL the hairs that were taken out and ALL the hairs that grew back (not just a sample section). Otherwise, it is just hairs that grew back after being plucked.

Basic high school science teaches us about conservation of energy or mass in the universe. Many have tried to invent the perpetual engine or create gold from lead with no success. If Dr. Gho really figured out a way to clone hair, then he will be famous. If you would like to believe in it, that is your prerogative… but simply looking at someone’s diary or posts on the Internet is not a way to validate or document science.

The method and presentation of Dr. Gho’s study has serious issues and it does and (will) confuse many readers. A credible review by a third party should be something that Dr. Gho should want to do, if he is legitimate.

P.S. I understand that you’re very excited for my answer to your question, but sending a dozen emails and blog comments demanding that I answer right away is unnecessary.

 

Press Release - RepliCel Provides Quarterly Update

Snippet from the press release:

RepliCel Life Sciences Inc. is pleased to report that the six-month post injection follow-up period of its TS001-2009 clinical trial is nearing completion.

To date, 17 of 19 subjects have had their six-month follow-up visit, during which time subjects had their overall health evaluated. This included subjective and objective assessment of verum and placebo injected sites and digital images were taken of the scalp and injection areas.

Read the full text — RepliCel Provides Quarterly Update on First-In-Man Clinical Trials

 

If Hair Cloning Ever Goes Mainstream, Would FUE Become the Gold Standard for Surgery?

Hi Dr. Rassman,

My understanding from reading your blog is that FUE is over-hyped because it does not produce a linear scar, but is still inferior to the strip method in producing the most number of grafts with the least amount of transection. If hair cloning technology was to ever become a mainstream option that hair transplant surgeons offered, would that then make FUE the gold standard/go-to choice since the number of grafts needed could be created from a smaller amount of donor follicles?

Thanks

The point of the post you’re referencing from a couple weeks ago (FUE Back into the Linear Scar vs Scar Revision) was that once a strip surgery has been done and a linear scar is already present, a FUE procedure should not be the harvesting method of choice.

To answer your question on cloning, if the clone somehow came from the scalp, then FUE would be used, but if the cloned hair came from a petri dish, then no harvesting mechanism will be needed and the cloned hair would be put directly into the recipient site.

 

Since There Has Been No Leaked Information, Are Regeneration Attempts Failing?

Since Acell has failed and seemed a year ago to be “A Cure for Baldness in Five Years” its seems to me that the only 2 research institutes that are really getting substancial funding are Aderans Research and Replicel. Aderans uses a small piece of tissue that is removed from the neckline…”Cells are cultivated in controlled conditions where they are encouraged to multiply by the addition of proprietary growth media. When enough new cells are formed, they are returned to the scalp, where they are injected and elicit new hair growth and thickness, ultimately producing more hair than the client had before.” Replicel has a way to isolate dermal sheath cup cells and cultivate them. They are hopeful that injecting them into the scalp will cause regrowth on the scalp.

Since both Aderans Research and Replicel are in phase 2 of their clinical trials one would think that unless the subjects of the trial were locked in a room for 6 months someone would obviously have come out and said that these injections are working. If so…investors and inside traders wouldn’t flinch to buy Replicel stock (Aderans Research is a private company.) But Replicels stock…regardless of its clinical studies that have been going on for all this time…has a low volume of trade and is at 2.35 a share. With all of this put together…it seems blatantly obvious that besides the procedure being safe…both Replicel and Aderans Research Institute’s attempts at regenerating hair follicles is failing. What is your take on this?

I guess that is one way to look at it. I am unaware of any leaked information, and I’m not even familiar with the ins and outs of these particular trials. I’d have to assume there are non-disclosure or confidentiality agreements which prevent participants from discussing their results (if any). If they are successful, the results will be announced when they’re ready. Rushing things isn’t going to help.

As for looking to insider trading as a sure-fire way to know if a product is coming to market… good luck with that.

 

SMP and Future Hair Cloning?

Hi,
I read about Scalp MicroPigmentation (SMP) and I think this might be a good choice for me, because I am not candidates for hair transplant surgery. However, I am waiting for the day that the hair cloning technology can be used by people like me. My question is: Is SMP a barrier for future hair cloning?

Thanks

When properly designed, Scalp MicroPigmentation (SMP) can work with hair transplants and possibly with a good cloning process once cloning is practical. Hair cloning is “not ready for prime time”, but I expect that once it is viable, any good cloning procedure must restore a normal appearance, including the leading edge of the hairline which is critical to a normal look.

This process is often ignored by tattoo people who do SMP type of work, partly because the patient pushes a hairline design that may not be normal, or the tattoo person does not appreciate the blend between the natural balding process, the maturing hairline, and what they should look like.

The influence of someone like Dr. Pak (who designs all of our SMP work) is critical to the excellent results we obtain. I would imagine that the same conditions would apply to the cloning process.

 

In the News - Interview with RepliCel’s Chief Medical Officer

Snippet from the article/interview:

For over a decade, leading hair biology scientists. Dr. Rolf Hoffmann and Dr. Kevin McElwee, have been studying the potential of dermal sheath cup cells to spark hair regeneration and the rejuvenation of miniaturized hair follicles. Hoffmann, RepliCel’s Chief Medical Officer, discusses his research, the process of developing this treatment, and the critical steps the company is taking along the way to ensure that it is successful.

Read the rest — Equities.com Interviews Dr. Rolf Hoffmann, Chief Medical Officer, RepliCel Life Sciences Inc.

Interesting reading! What little I know of RepliCel has been written before here, but this interview explains about their study of the dermal sheath cup cells and how this differs from others doing similar research.

 

What’s Next for ACell and Hair Multiplication?

Since Dr. Hitzig appears to have reversed his stance on acell 2 hairs for one process on a bald scalp, how much hair density did he say is required for the new hair to grow?

Are you planning to do studies using denser sites for transplantation? Or do you think we’ve been sold a too good to be true situation.
He must know others would try and duplicate the process. And fail.

Perhaps I wasn’t clear enough on the ACell matter…

ACell for use in hair cloning or hair multiplication (plucked hairs) does not work. I am not at all sure if it even has a future in hair multiplication. We aren’t planing further studies, but I can’t speak for other doctors that might be trying to get it to work as originally claimed.

 

German Stem Cell Hair Replication Technique

Dr. Rassman,

What can you tell us about this new German development?

YouTube

Exciting stuff. Thanks for sending the link! I’ve embedded the video below.

The first two researchers are certainly stimulated to find a cure (they are very bald) so I would trust them. Growing hair follicles in a petri dish has been done before by Dr. Jahoda in the 1990s (here and here). When grown in the petri dish, it is exciting, but moving them into a scalp and having them grow is much, much harder.

 

Could Hair Cloning or SMP Work for Someone with DUPA?

Hi Dr. Rassman:

Once again, thank you for contributing to a great blog.

I am a 32 yr old white male with dark hair. Approximately 2 years ago I first noticed thinning hair on the Crown (about the size of a ping pong ball). I went on propecia and have been on it ever since. There has not been any visible progression (at least to the naked eye). In terms of family history, all of my immediate family members have their hair except once uncle in his 50s has a bald spot around his crown. My one deceased grandfather buzzed his hair but according to my Dad, still hair hair (not completely bald).

I went for a consultation with a hair transplant doctor who advised me that I would need around 2000 grafts to cover that space but since I have an unstable permanent zone (i.e. miniaturization) he did not recommend it.

  1. The doctor did not use the acronym “DUPA” but is that what he was essentially saying?
  2. I have had fine hair since I was in my teens. Is DUPA progressive or stable? I have what appears to be a full head of hair - will it stabalize here or continue to progress?
  3. Dr. Bernstein states that those with DUPA can look “fine” if they keep their hair very short. Does he mean short as in the same look achieved through scalp micro pigmentation?
  4. Can scalp micro pigmentation be of use to someone with DUPA?
  5. There has been a lot of discussion about hair cloning/manipulation being available commercially within 10 years (according to Dr. Bernstein). In your professional opinion, do you think such an advancement be of any use to someone with DUPA?

1. Genetic male pattern baldness doesn’t include the permanent zone, so diffuse loss there could be DUPA.

2. DUPA is often progressive, but it can be stable for a number of years. These conditions tend to be unstable if it is associated with genetic balding.

3. No, not that short. I am sure Dr. Bernstein means clipping it to 1/4 or 1/3rd inch.

4. It can be, but I do not like to generalize on this without examining your scalp and hair loss.

5. That 10 year mark has been moving every year. There’s no use speculating on what cloning can or can’t do for treating various issues, as it won’t be commercially available in the near future. If hair cloning becomes closer to reality, I’m sure the answers will come.

 

Hair Cloning Presentation By Dr Ken Washenik (Video)

Hello doctor, I don’t know if you already have seen this but I think you might find this interesting. Maybe you have comments on it?

YouTube

Thanks for sending the video. I had not seen it before. The video is of Dr. Ken Washenik from Aderans Research discussing where his company is at in the hair cloning race at the ICRAH (International Congress Research Against Hair Loss) meeting in France earlier this year. Even though it seems his voice was replaced with a female speaker in the video, this is very exciting stuff. It appears that we are getting closer to the final solution to the hair loss problem.

I’ve embedded the video below: